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US Patent 12109238 Chimeric antigen receptor-modified NK-92 cells

Patent 12109238 was granted and assigned to ImmunityBio on October, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
ImmunityBio
ImmunityBio
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Current Assignee
ImmunityBio
ImmunityBio
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121092380
Patent Inventor Names
Laurent H. Boissel0
Hans G. Klingemann0
Date of Patent
October 8, 2024
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Patent Application Number
178122640
Date Filed
July 13, 2022
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Patent Citations
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US Patent 9181322 Genetically modified human natural killer cell lines
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US Patent 10138462 Natural killer cell lines and methods of use
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US Patent 10738279 Modified NK-92 cells for treating cancer
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US Patent 10765701 Elimination of CD19-positive lymphoid malignancies by CD19-CAR expressing NK cells
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US Patent 8034332 Interleukin-secreting natural killer cell lines and methods of use
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US Patent 7618817 Genetically modified human natural killer cell lines
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US Patent 8313943 Genetically modified human natural killer cell lines
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US Patent 9150636 Genetically modified human natural killer cell lines
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Patent Primary Examiner
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Amy E Juedes
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CPC Code
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C12N 5/0646
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C07K 16/32
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A61K 35/17
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A61K 35/28
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A61K 39/3955
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A61K 45/06
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A61P 35/00
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C07K 14/70517
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Patent abstract

Provided are NK-92 cells expressing a chimeric antigen receptor (CAR). The CAR can comprise an intracellular domain of FcεRIγ. Also described are methods for treating a patient having or suspected of having a disease that is treatable with NK-92 cells, such as cancer or a viral infection, comprising administering to the patient NK-92-CAR cells.

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