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US Patent 12103982 T cell activating bispecific antigen binding molecules

Patent 12103982 was granted and assigned to Hoffmann-La Roche Limited on October, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Hoffmann-La Roche Limited
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Current Assignee
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Hoffmann-La Roche Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121039820
Patent Inventor Names
Pablo Umana0
Christian Klein0
Ralf Hosse0
Ekkehard Moessner0
Peter Bruenker0
Christiane Neumann0
Date of Patent
October 1, 2024
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Patent Application Number
174707780
Date Filed
September 9, 2021
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Patent Citations
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US Patent 8703132 Bispecific, tetravalent antigen binding proteins
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US Patent 8709421 Combination of the application of antibodies for immunostimulation together with glucocorticoids
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US Patent 8796424 Tri- or tetraspecific antibodies
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US Patent 8834877 Anti-folate receptor alpha antibodies and uses thereof
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US Patent 8969526 Antibody Fc variants
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US Patent 9068008 Antibodies to carcinoembryonic antigen (CEA), methods of making same, and uses thereof
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US Patent 9266938 Mutant interleukin-2 polypeptides
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US Patent 9266967 Bivalent, bispecific antibodies
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...
Patent Primary Examiner
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Lei Yao
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CPC Code
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C07K 16/468
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C07K 16/30
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C12N 15/73
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C07K 16/28
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C07K 16/464
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C07K 16/2809
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A61K 39/001102
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Patent abstract

The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells comprising a common light chain. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

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