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US Patent 12084651 Surface display of whole antibodies in eukaryotes

Patent 12084651 was granted and assigned to Merck Sharp & Dohme Limited on September, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Merck Sharp & Dohme Limited
Merck Sharp & Dohme Limited
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Current Assignee
Merck Sharp & Dohme Limited
Merck Sharp & Dohme Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120846510
Patent Inventor Names
Natarajan Sethuraman0
Dongxing Zha0
Piotr Bobrowicz0
Stefan Wildt0
Bianka Prinz0
Date of Patent
September 10, 2024
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Patent Application Number
173439050
Date Filed
June 10, 2021
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Patent Citations
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US Patent 7132273 Cell wall anchor proteins derived from yeast, genes thereof and cell surface expression systems using the same
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US Patent 7166423 Direct selection of cells by secretion product
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US Patent 7198921 Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
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US Patent 7259007 Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
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US Patent 7435553 Isolating cells expressing secreted proteins
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US Patent 7479389 ARG1, ARG2, ARG3, HIS1, HIS2, HIS5, HIS6 genes and methods for stable genetic integration
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US Patent 8067339 Surface display of whole antibodies in eukaryotes
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US Patent 9260712 Surface display of whole antibodies in eukaryotes
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Patent Primary Examiner
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Lynn A Bristol
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CPC Code
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G01N 33/6854
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C12N 15/1037
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Patent abstract

Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.

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