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US Patent 12060436 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof

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 US Patent 12060436 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof

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Patent abstract

Provided are heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the C

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120604360
Patent Inventor Names
Adam Louis Corper0
Dunja Urosev0
Dustin Weyland Blue Bleile0
Mario Sanches0
Paula Irene Lario0
Stacey A. L. Tom-Yew0
Surjit Dixit0
Thomas Spreter Von Kreudenstein0
Date of Patent
August 13, 2024
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Patent Application Number
173431980
Date Filed
June 9, 2021
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Patent Citations
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US Patent 11078296 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
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US Patent 11161915 Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
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US Patent 7183076 Method for making multispecific antibodies having heteromultimeric and common components
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US Patent 7635472 Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
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US Patent 7642228 Method for making heteromultimeric polypeptides
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US Patent 7695936 Knobs and holes heteromeric polypeptides
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US Patent 7769573 System and method for modeling interactions
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US Patent 7923221 Methods of making antibody heavy and light chains having specificity for a desired antigen
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US Patent 7947271 Methods of decreasing tumor volume and reducing tumor burden using TNF-receptor-coupling agents
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US Patent 7951917 Method for making multispecific antibodies having heteromultimeric and common components
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US Patent 8501185 Dimeric molecular complexes
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US Patent 8592562 Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
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US Patent 8623361 Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders
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US Patent 8771988 Protein expression from multiple nucleic acids
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US Patent 9079965 Bispecific antibody
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US Patent 9499634 Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
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US Patent 9527927 Modified polypeptides for bispecific antibody scaffolds
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US Patent 9562109 Stable heterodimeric antibody design with mutations in the Fc domain
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US Patent 9574010 Stable heterodimeric antibody design with mutations in the Fc domain
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US Patent 9708388 Antibody light chains
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US Patent 9732155 Crystal structures of heterodimeric Fc domains
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US Patent 9771573 Methods of quantitating heavy and light chain polypeptide pairs
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US Patent 9914785 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
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US Patent 9988460 Crystal structures of heterodimeric Fc domains
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US Patent 10000576 Bispecific antigen-binding constructs targeting HER2
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US Patent 10077298 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
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US Patent 10392438 Bispecific antibodies
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US Patent 10457742 Stable heterodimeric antibody design with mutations in the Fc domain
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US Patent 10508154 Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
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US Patent 11286293 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
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US Patent 11306156 Modified antigen binding polypeptide constructs and uses thereof
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Patent Primary Examiner
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Phuong Huynh
0

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