Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ian Slaymaker0
Bernd Zetsche0
Michael Packer0
Yi Yu0
David A. Born0
Nicole Gaudelli0
Seung-Joo Lee0
Date of Patent
June 25, 2024
0Patent Application Number
178151280
Date Filed
July 26, 2022
0Patent Citations
Patent Primary Examiner
Patent abstract
The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed “ABE8” having unprecedented levels (e.g., >60-70%) of efficiency.
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