A portable cooler container with active temperature control, comprising: a container body having a chamber configured to receive and hold one or more containers of medicine; a lid operable to access the chamber; and a temperature control system comprising one or more thermoelectric elements configured to actively heat or cool at least a portion of the chamber, circuitry configured to control an operation of the one or more thermoelectric elements to heat or cool at least a portion of the chamber to a predetermined temperature or temperature range; and a display screen disposed on one of the container body and the lid, the display screen configured to selectively display one or more of information associated with the operation of the portable cooler, information associated with the containers of medicine in the portable cooler, information associated with scheduled taking of the containers of medicine, and advertisements.