A fracturing system includes a first trailer-mounted fracturing manifold including a plurality of first fluidly-connected junctions and a second trailer-mounted fracturing manifold including a plurality of second fluidly-connected junctions. A flexible conduit fluidly connects an initial junction of the first junctions to a terminal junction of the second junctions to place the first trailer-mounted fracturing manifold in series connection with the second trailer-mounted fracturing manifold.