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US Patent 11998601 Messenger RNA therapy for treatment of articular disease

Patent 11998601 was granted and assigned to Translate Bio on June, 2024 by the United States Patent and Trademark Office.

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 US Patent 11998601 Messenger RNA therapy for treatment of articular disease

Article

Patent abstract

The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a subject in need of delivery a composition comprising an mRNA encoding a protein, such that the administering of the composition results in expression of the protein encoded by the mRNA in the joint.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Translate Bio
Translate Bio
0
Current Assignee
Translate Bio
Translate Bio
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119986010
Patent Inventor Names
Frank DeRosa0
Michael Heartlein0
Date of Patent
June 4, 2024
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Patent Application Number
171179810
Date Filed
December 10, 2020
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Patent Citations
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US Patent 7422902 Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
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US Patent 7745651 Cationic lipids and methods of use
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US Patent 7799565 Lipid encapsulated interfering RNA
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US Patent 7803397 Polyethyleneglycol-modified lipid compounds and uses thereof
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US Patent 7901708 Liposomal apparatus and manufacturing methods
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US Patent 8101741 Modified siRNA molecules and uses thereof
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US Patent 8188263 Modified siRNA molecules and uses thereof
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US Patent 8236943 Compositions and methods for silencing apolipoprotein B
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US Patent 8329070 Liposomal apparatus and manufacturing method
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US Patent 8513403 Modified siRNA molecules and uses thereof
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US Patent 8569256 Cationic lipids and methods for the delivery of therapeutic agents
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US Patent 8710200 Engineered nucleic acids encoding a modified erythropoietin and their expression
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US Patent 8822663 Engineered nucleic acids and methods of use thereof
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US Patent 8853377 mRNA for use in treatment of human genetic diseases
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US Patent 8883202 Lipid compositions
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US Patent 8936942 Polyethyleneglycol-modified lipid compounds and uses thereof
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US Patent 8980864 Compositions and methods of altering cholesterol levels
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US Patent 8999351 Lipids and compositions for the delivery of therapeutics
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US Patent 8999380 Modified polynucleotides for the production of biologics and proteins associated with human disease
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US Patent 8999950 Compositions and methods for silencing aldehyde dehydrogenase
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US Patent 9018187 Cationic lipids and methods for the delivery of therapeutic agents
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US Patent 9051567 Methods for increasing efficacy of lipid formulated siRNA
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US Patent 9061059 Modified polynucleotides for treating protein deficiency
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US Patent 9074208 Modified siRNA molecules and uses thereof
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US Patent 9089604 Modified polynucleotides for treating galactosylceramidase protein deficiency
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US Patent 9095552 Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1
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US Patent 9107886 Modified polynucleotides encoding basic helix-loop-helix family member E41
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US Patent 9114113 Modified polynucleotides encoding citeD4
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US Patent 9181319 Engineered nucleic acids and methods of use thereof
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US Patent 9186325 Lipids and compositions for the delivery of therapeutics
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US Patent 9186372 Split dose administration
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US Patent 9187748 Compositions and methods for silencing ebola virus gene expression
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US Patent 9192651 Modified polynucleotides for the production of secreted proteins
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US Patent 9220755 Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
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US Patent 9220792 Modified polynucleotides encoding aquaporin-5
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US Patent 9233141 Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
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US Patent 9254311 Modified polynucleotides for the production of proteins
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US Patent 9295689 Formulation and delivery of PLGA microspheres
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US Patent 9301993 Modified polynucleotides encoding apoptosis inducing factor 1
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US Patent 9303079 Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
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US Patent 9334328 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
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US Patent 9345780 Site specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
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US Patent 9352042 Trialkyl cationic lipids and methods of use thereof
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US Patent 9352048 Carbohydrate conjugates as delivery agents for oligonucleotides
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US Patent 9364435 Lipid formulations for nucleic acid delivery
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US Patent 9370581 Carbohydrate conjugates as delivery agents for oligonucleotides
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US Patent 9370582 Carbohydrate conjugates as delivery agents for oligonucleotides
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US Patent 9943595 Messenger RNA therapy for treatment of articular disease
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US Patent 10087247 Methods and compositions for delivering mRNA coded antibodies
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US Patent 10143758 Liver specific delivery of messenger RNA
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US Patent 10846267 Masterless backup and restore of files with multiple hard links
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Patent Primary Examiner
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Robert M Kelly
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