Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeffrey N. Agar0
Joseph Salisbury0
Date of Patent
May 21, 2024
0Patent Application Number
175747420
Date Filed
January 13, 2022
0Patent Citations
Patent Primary Examiner
Patent abstract
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
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