Cable channel apparatus are provided that may be employed for routing system cables through open spaces defined within chassis walls, barriers or other fixed surfaces that separate different compartments or areas of an information handling system chassis. The cable channel apparatus may form a seal around the inserted system cables that prevents recirculation of cooling air through the open spaces between the different compartments. In one example, the cable channel apparatus may be employed to form such a seal around system cables that are routed through an open space to pass though or around a fan gantry that is mounted within a chassis of an information handling system chassis.