Patent 11976134 was granted and assigned to Precigen on May, 2024 by the United States Patent and Trademark Office.
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.