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US Patent 11952428 BCMA chimeric antigen receptors and uses thereof

Patent 11952428 was granted and assigned to Novartis on April, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Dexiu Bu0

Aida Abujoub0

Chonghui Zhang0

Brian Holmberg0

Tony Fleming0

John Blankenship0

Lu Huang0

Connie Hong0

Date of Patent

April 9, 2024

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Patent Application Number

181709410

Date Filed

February 17, 2023

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Patent Citations

US Patent 7049136 Redirection of cellular immunity by receptor chimeras

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US Patent 7052906 Synthetic transmembrane components

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US Patent 7067318 Methods for transfecting T cells

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US Patent 7070995 CE7-specific redirected immune cells

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US Patent 7083785 Methods of treatment by administering an anti-BCMA antibody

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US Patent 7129332 Anti-EGFRvIII scFvs with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof

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US Patent 7144575 Methods for selectively stimulating proliferation of T cells

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US Patent 7172869 Methods for transfecting T cells

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Patent Primary Examiner

Zachary S Skelding

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Patent abstract

The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

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