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US Patent 11944612 Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Patent 11944612 was granted and assigned to Global Blood Therapeutics on April, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Global Blood Therapeutics

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Current Assignee

Global Blood Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Athiwat Hutchaleelaha0

Joshua Eli Lehrer-Graiwer0

Naveen Bejugam0

Eleanor L. Ramos0

Date of Patent

April 2, 2024

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Patent Application Number

178818740

Date Filed

August 5, 2022

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Patent Citations

US Patent 9012450 Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation

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US Patent 9018210 Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

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US Patent 9150569 Nitrogen-containing heterocyclic compound having inhibitory effect on production of kynurenine

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US Patent 9248199 1:1 adducts of sickle hemoglobin

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US Patent 9422279 Compounds and uses thereof for the modulation of hemoglobin

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US Patent 9447071 Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

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US Patent 9458139 Compounds and uses thereof for the modulation of hemoglobin

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US Patent 9604999 Compounds and uses thereof for the modulation of hemoglobin

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Patent Primary Examiner

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Patent abstract

Provided herein are methods for treating sickle cell disease, comprising administering to a subject 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)-methoxy)benzaldehyde (Compound 1), or a polymorph thereof, in certain dosing regimens.

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