Endodontic instruments are used to clean and enlarge the endodontic cavity space (ECS), also known as the root canal system, of a human tooth. This document describes novel endodontic instruments that are radially compressible, and methods for their use. Some embodiments include a shank and a body with a working surface. At least a portion of the working surface may define a center of mass path that spirals. The center of mass of a transverse cross-section of the working surface at the shank end can be offset from the axis of rotation of the instrument.