Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Curtis Hewitt0
Richard Jude Samulski0
Date of Patent
March 26, 2024
0Patent Application Number
180607990
Date Filed
December 1, 2022
0Patent Citations
Patent Primary Examiner
Patent abstract
This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.
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