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US Patent 11939328 Quinoline compounds as inhibitors of KRAS

Patent 11939328 was granted and assigned to Incyte on March, 2024 by the United States Patent and Trademark Office.

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 US Patent 11939328 Quinoline compounds as inhibitors of KRAS

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Patent abstract

Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Incyte
Incyte
0
Current Assignee
Incyte
Incyte
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119393280
Patent Inventor Names
Alexander Sokolsky0
Artem Shvartsbart0
Bin Hu0
Chao Qi0
Matthew McCammant0
Qinda Ye0
Wenqing Yao0
Wenyu Zhu0
Xiaozhao Wang0
Date of Patent
March 26, 2024
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Patent Application Number
180463030
Date Filed
October 13, 2022
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Patent Citations
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US Patent 7592453 Fused quinoline derivative and use thereof
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US Patent 7897609 Aryl substituted imidazonaphthyridines
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US Patent 7943770 Fused quinoline derivative and use thereof
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US Patent 7973163 Fused quinoline derivative and use thereof
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US Patent 8034802 Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus
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US Patent 8143270 2-amino 1
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US Patent 8158794 Hydroxyalkyl substituted imidazoquinoline compounds and methods
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US Patent 8207187 Use of pyrroloquinoline compounds to kill clinically latent microorganisms
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US Patent 8241917 Isotope-doped nano-material, method for making the same, and labeling method using the same
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US Patent 8354405 6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
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US Patent 8455491 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and derivatives and pharmaceutical compositions comprising the same
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US Patent 8513250 Imidazolo-heteroaryl derivatives with antibacterial properties
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US Patent 8546395 6-cycloamino-3-(1
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US Patent 8557984 Imidazo [4, 5-C] quinoline derivatives as bromodomain inhibitors
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US Patent 8563565 Pyrazoloquinoline derivatives
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US Patent 8637670 Imidazo [4,5-C]quinoline derivatives and their use in the treatment of tumors and/or inflammation
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US Patent 8658666 Substituted imidazoquinolines and imidazonaphthyridines
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US Patent 8697744 Substituted 5,6-dihydro-4H-thiazolo[4,5-E]indazoles and their use as positive allosteric modulators of metabotropic glutamate receptors
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US Patent 8822448 Pyrazoloquinoline compound
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US Patent 8846710 Method of preferentially inducing the biosynthesis of interferon
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US Patent 8895581 1
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US Patent 9045419 Condensed-cyclic compound and organic light emitting diode having organic layer including the same
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US Patent 9062046 Substituted imidazoquinoline derivatives as kinase inhibitors
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US Patent 9169246 Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
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US Patent 9403769 Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics
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US Patent 9550776 Pyridinylpyrazoloquinoline compounds
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US Patent 9573947 Salt of pyrazoloquinoline derivative, and crystal thereof
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US Patent 9694006 Use of pyrroloquinoline compounds to kill clinically latent microorganisms
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US Patent 9771327 Compounds and methods for the treatment of cystic fibrosis
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US Patent 9873694 Imidazole quinoline-based immune system modulators
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US Patent 9960359 Arylamine-based compound and organic light emitting diode comprising the same
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US Patent 10039753 Imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives as LRRK2 inhibitors
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US Patent 10081637 Pyrazole compounds as modulators of FSHR and uses thereof
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US Patent 10208055 Pyrazole compounds as modulators of FSHR and uses thereof
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US Patent 10249826 Compound, organic electroluminescent element and electronic device
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US Patent 10251870 Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity
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US Patent 10326084 Organic electroluminescent element, compound, and light emitting device, display device and lighting system, using said element
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US Patent 10351557 Compounds for electronic devices
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US Patent 10493071 Use of pyrroloquinoline compounds to kill clinically latent microorganisms
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US Patent 10544138 Tricyclic kinase inhibitors of MELK and methods of use
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US Patent 11053240 2-amino-quinoline derivatives
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Patent Primary Examiner
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Laura L. Stockton
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CPC Code
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C07D 471/04
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