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US Patent 11932685 Fc variants with altered binding to FcRn

Patent 11932685 was granted and assigned to Xencor on March, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Xencor
Xencor
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Current Assignee
Xencor
Xencor
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119326850
Patent Inventor Names
Bassil Dahiyat0
Sher Bahadur Karki0
John R. Desjarlais0
Gregory Alan Lazar0
Aaron Keith Chamberlain0
Date of Patent
March 19, 2024
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Patent Application Number
170792990
Date Filed
October 23, 2020
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Patent Citations
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US Patent 7056695 TNF-α variants
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US Patent 7083784 Molecules with extended half-lives, compositions and uses thereof
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US Patent 7101974 TNF-αvariants
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US Patent 7117096 Structure-based selection and affinity maturation of antibody library
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US Patent 7217797 Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
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US Patent 7244823 TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
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US Patent 7247301 Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
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US Patent 7276585 Immunoglobulin variants outside the Fc region
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...
Patent Primary Examiner
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Chun W Dahle
0
Patent abstract

The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

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