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US Patent 11926832 Ketohexokinase (KHK) iRNA compositions and methods of use thereof

Patent 11926832 was granted and assigned to Alnylam Pharmaceuticals on March, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Alnylam Pharmaceuticals

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Current Assignee

Alnylam Pharmaceuticals

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Frederic Tremblay0

James D. McIninch0

Mark K. Schlegel0

Leila Noetzli0

Adam Castoreno0

Date of Patent

March 12, 2024

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Patent Application Number

180609900

Date Filed

December 2, 2022

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Patent Citations

US Patent 10370666 Ketohexokinase (KHK) iRNA compositions and methods of use thereof

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US Patent 9399775 RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases

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US Patent 9796974 Modified RNAi agents

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US Patent 11136582 Ketohexokinase (KHK) iRNA compositions and methods of use thereof

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Patent Primary Examiner

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CPC Code

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Patent abstract

The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the ketohexokinase (KHK) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a KHK gene and to methods of treating or preventing a KHK-associated disorder in a subject.

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