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US Patent 11920202 Unbiased identification of tumor rejection mediating neoepitopes

Patent 11920202 was granted and assigned to University of Connecticut on March, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

University of Connecticut

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Current Assignee

University of Connecticut

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Cory A Brennick0

Ion I Mandoiu0

Marmar Moussa0

Pramod K. Srivastava0

Mariam M George0

Date of Patent

March 5, 2024

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Patent Application Number

172253740

Date Filed

April 8, 2021

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Patent Citations

US Patent 10426824 Compositions and methods of identifying tumor specific neoantigens

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US Patent 8140270 Methods and systems for medical sequencing analysis

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US Patent 10055540 Neoantigen identification, manufacture, and use

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US Patent 10155031 Individualized vaccines for cancer

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US Patent 10501801 Identification of tumor-protective epitopes for the treatment of cancers

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Patent Primary Examiner

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Patent abstract

Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC

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