Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Frank DeRosa0
Michael Heartlein0
Anusha Dias0
Date of Patent
March 5, 2024
0Patent Application Number
173250920
Date Filed
May 19, 2021
0Patent Citations
Patent Primary Examiner
CPC Code
Patent abstract
The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro. In some embodiments, methods according to the present invention comprise providing an mRNA sample containing capped and uncapped mRNA, providing a cap specific binding substance under conditions that permit the formation of a complex between the cap specific binding substance and the capped mRNA, and quantitatively determining the amount of the complex as compared to a control, thereby quantifying mRNA capping efficiency.
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