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US Patent 11919839 Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

Patent 11919839 was granted and assigned to Valo Health on March, 2024 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

David R. Lancia, Jr.0

Xiaozhang Zheng0

Cuixian Liu0

Jennifer R. Thomason0

Kenneth W. Bair0

Aleksandra Rudnitskaya0

Bingsong Han0

Pui Yee Ng0

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Date of Patent

March 5, 2024

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Patent Application Number

172385290

Date Filed

April 23, 2021

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Patent Citations

US Patent 7135493 HDAC inhibitor

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US Patent 7342022 Compounds in the treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3

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US Patent 7375228 Histone deacetylase inhibitors

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US Patent 7399786 Derivatives of amino acids for treatment of obesity and related disorders

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US Patent 7402603 Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination

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US Patent 7435729 Compounds and methods for modulation of estrogen receptors

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US Patent 7507858 Histone deacetylase inhibitors

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US Patent 7517898 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

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Patent Primary Examiner

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CPC Code

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Patent abstract

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

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