A refrigerator and a home appliance include a cabinet with a storage space formed therein, and a door configured to open and close the storage space, and including a door body filled with an insulator and a door panel detachably mounted on a front surface of the door body, where the door panel includes a panel defining a front appearance of the door, and a panel bracket extending along at least one end of a perimeter of a rear surface of the panel and coupled to the door body, and the panel bracket includes a coupling part coupled to the rear surface of the panel, a support part formed along an end of the coupling part and configured to support an end of the panel, and a mounting part protruding rearward from a rear surface of the coupling part and coupled to the door body.