Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tian Tian0
Eileen Spindler0
Charles Johnson0
Clint Davis0
Date of Patent
February 6, 2024
0Patent Application Number
176802890
Date Filed
February 25, 2022
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The present disclosure relates to methods for increasing observed editing rates in the surviving bacteria cells. The compositions and methods presented herein in combination lead to a phenomenon of “edit or die.” Although less cells survive plating and editing, a large percentage of cells that do survive are multiple editors. In one experiment it was found that if a cell survives transformation, plating, and editing, 75% of the surviving cells are multiple editors; that is, 75% of the surviving cells were simultaneously edited with edits at two or more different locations within the bacterial genome.
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