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US Patent 11878009 Anticancer combination of chidamide and celecoxib salts

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Yi-Hong Wu0

Cheng-Han Chou0

Ye-Su Chao0

Sz-Hao Chu0

Mu-Hsuan Yang0

Chia-Nan Chen0

Jia-Shiong Chen0

Date of Patent

January 23, 2024

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Patent Application Number

165667440

Date Filed

September 10, 2019

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Patent Citations

US Patent 10287353 Combination therapies of HDAC inhibitors and PD-1 inhibitors

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US Patent 10548889 Compositions of CXCR4 inhibitors and methods of preparation and use

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US Patent 10385131 Combination therapies of HDAC inhibitors and PD-L1 inhibitors

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US Patent 10624968 Compounds for treating cancer

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US Patent 9573901 Crystal form of chidamide, preparation method and use thereof

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US Patent 10246462 Chemokine receptor modulators and uses thereof

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Patent Primary Examiner

Kara R McMillian

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CPC Code

0

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Patent abstract

The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.

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