Patent 11857638 was granted and assigned to Promega (company) on January, 2024 by the United States Patent and Trademark Office.
Conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. The quinone-containing linker may be reduced intracellularly to trigger release of the drug or probe. These conjugates may selectively deliver a drug or probe to a site of action of interest for local release of the active drug or probe.