A temperature-controlled medication packaging system includes a storage with a temperature-controlled interior containing at least one medication. The packaging system further includes at least one shipping container and at least one coolant that is sized to fit within the at least one shipping container. A first robot is adapted to retrieve the at least one medication from the storage and transport the at least one medication to a second robot. The second robot is adapted to receive the at least one medication from the first robot and to bring the at least one medication and the at least one shipping container and the at least one coolant together for packaging.