Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Szymon Klossowski
Trupta Purohit
EunGi Kim
Hao Li
Jing Deng
Hongzhi Miao
Tomasz Cierpicki
Jolanta Grembecka
...
Date of Patent
October 17, 2023
Patent Application Number
17468308
Date Filed
September 7, 2021
Patent Citations
Patent Primary Examiner
Patent abstract
Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.
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