Is a
Patent attributes
Patent Applicant
Patent Jurisdiction
Patent Number
Patent Inventor Names
Siler Panowski
Regina Junhui Lin
Barbra Johnson Sasu
Thomas John Van Blarcom
Date of Patent
October 17, 2023
Patent Application Number
16804545
Date Filed
February 28, 2020
Patent Citations
Patent Primary Examiner
Patent abstract
Provided herein are PD-1 chimeric cytokine receptors. When present on chimeric antigen receptor (CAR)-bearing immune cells, such receptors allow for increased immune cell activation, proliferation, persistence, and/or potency, when engaged with PD-1 ligands or activation with an anti-PD-1 antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.
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