Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Bruce C. Schnepp
Philip R. Johnson
Date of Patent
September 26, 2023
Patent Application Number
17365846
Date Filed
July 1, 2021
Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
Provided herein are isolated DNA vectors comprising a heterologous gene, wherein the DNA vector is devoid of bacterial plasmid DNA and/or bacterial signatures, which can abrogate persistence in vivo. The invention also features pharmaceutical compositions (non-immunogenic pharmaceutical compositions) including the DNA vectors of the invention, which can be used for induction of long-term, episomal expression of a heterologous gene in a subject. The invention involves methods of treating a subject by administering the DNA vectors of the invention, including methods of treating disorders associated with a defect in a target gene.
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