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US Patent 11759504 PTH compounds with low peak-to-trough ratios

Patent 11759504 was granted and assigned to Ascendis Pharma on September, 2023 by the United States Patent and Trademark Office.

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Is a

Patent attributes

Patent Applicant

Ascendis Pharma

Current Assignee

Ascendis Pharma

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Thomas Wegge

Lars Holten-Andersen

Guillaume Maitro

Kennett Sprogøe

David Brian Karpf

Joachim Zettler

Mathias Krusch

Felix Cleemann

Date of Patent

September 19, 2023

Patent Application Number

16337955

Date Filed

September 28, 2017

Patent Citations

US Patent 8865220 Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres

US Patent 8946405 Controlled release from solid supports

US Patent 8906847 Prodrug comprising a drug linker conjugate

US Patent 7585837 Reversible pegylated drugs

US Patent 7820179 Pegylated PTH as PTH receptor modulators and uses thereof

US Patent 8101729 Pegylated amino acid derivatives and the process to synthesize the same

US Patent 8618124 Heterobifunctional polymeric bioconjugates

US Patent 8754190 Controlled release from macromolecular conjugates

Patent Primary Examiner

Christina Bradley

Patent abstract

The present invention relates to a pharmaceutical composition comprising a PTH compound, wherein after subcutaneous administration the pharmacokinetic profile of the PTH compound exhibits a peak to trough ratio of less than 4 within one injection interval.

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