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US Patent 11753632 Highly potent acid alpha-glucosidase with enhanced carbohydrates

Patent 11753632 was granted and assigned to Amicus Therapeutics on September, 2023 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
Amicus Therapeutics
Amicus Therapeutics
Current Assignee
Amicus Therapeutics
Amicus Therapeutics
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11753632
Patent Inventor Names
Hung V. Do
Russell Gotschall
Date of Patent
September 12, 2023
Patent Application Number
17249175
Date Filed
February 23, 2021
Patent Citations
‌
US Patent 7655226 Treatment of Pompe's disease
‌
US Patent 7658916 Methods of enhancing lysosomal storage disease therapy by modulation of cell surface receptor density
‌
US Patent 7785856 Acid alpha-glucosidase and fragments thereof
‌
US Patent 7858576 Method for targeting lysosomal enzymes
‌
US Patent 7910545 Combination enzyme replacement and small molecule therapy for treatment of lysosomal storage diseases
‌
US Patent 7981864 Methods and compositions for targeting proteins across the blood brain barrier
‌
US Patent 8785168 Formulations for lysosomal enzymes
‌
US Patent 8900552 Treatment of glycogen storage disease type II
...
Patent Primary Examiner
‌
Li N Komatsu
CPC Code
‌
A61K 48/005
‌
C12N 2510/02
‌
C12N 9/2465
‌
C12N 15/09
‌
C12Y 302/0102

Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.

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