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US Patent 11708597 Pin-based valve actuation system for processing biological samples

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Is a
Patent
Patent
0

Patent attributes

Patent Applicant
NeuMoDx Molecular
NeuMoDx Molecular
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Current Assignee
NeuMoDx Molecular
NeuMoDx Molecular
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
117085970
Date of Patent
July 25, 2023
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Patent Application Number
161218640
Date Filed
September 5, 2018
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Patent Citations
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US Patent 7323140 Moving microdroplets in a microfluidic device
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US Patent 7332130 Heat-reduction methods and systems related to microfluidic devices
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US Patent 7372616 Complex microdevices and apparatus and methods for fabricating such devices
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US Patent 7445901 Nuclease inhibitor cocktail
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US Patent 7473397 Device for chemical or biochemical analysis
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US Patent 7556858 Substrate with attached dendrimers
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US Patent 7569346 Method for separating analyte from a sample
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US Patent 7580533 Particulate flow detection microphone
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Patent Primary Examiner
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Lydia Edwards
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CPC Code
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B01L 2200/0684
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B01L 2200/0689
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B01L 2200/10
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B01L 2300/0654
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B01L 2300/0681
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B01L 2300/087
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B01L 2300/123
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B01L 2300/1827
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...

A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.

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