A multi-axis positioning stage or positioner includes a top plate supported and manipulatable by a plurality of prismatic joint actuators. Each actuator includes an actuator joint having four or five Degrees of Freedom (DOF) with the top plate. When one or more of the actuators extends or contracts, the pivot points, or four or five DOF actuator joints, of the remaining actuators are allowed to shift to move the top plate. The actuators can be disposed between at least one base plate or base structure, and can be fixed thereto.