This document describes a high efficiency dehumidification system (HEDS) and method of operating the same. The HEDS systems and physical implementations can include a variety of equipment, such as fans, filtration systems, fluid-conveying coils, piping or tubing, heat transfer coils, vents, louvers, dampers, valves, fluid chillers, fluid heaters, or the like. Any of the implementations described herein can also include controls and logic, responsive to one or more sensors or other input devices, for controlling the equipment for each implementation described herein.