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US Patent 11648318 Anti-transferrin receptor (TFR) antibody and uses thereof

Patent 11648318 was granted and assigned to Dyne Therapeutics on May, 2023 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Dyne Therapeutics

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Current Assignee

Dyne Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Romesh R. Subramanian0

Timothy Weeden0

Brendan Quinn0

Cody A. Desjardins0

John Najim0

Mohammed T. Qatanani0

Date of Patent

May 16, 2023

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Patent Application Number

178113960

Date Filed

July 8, 2022

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Patent Citations

US Patent 10550188 Nucleic acid-polypeptide compositions and uses thereof

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US Patent 11111309 Method of reducing expression of DUX4 in a muscle cell by administering an anti-transferrin receptor antibody linked to an oligonucleotide targeting DUX4

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US Patent 11168141 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 11230605 Anti-TfR antibodies and their use in treating proliferative and inflammatory disorders

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US Patent 11248056 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 11286305 Complex comprising anti-transferrin receptor antibody covalently linked to an oligonucleotide that targets DUX4 RNA

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US Patent 11369689 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 11390682 Methods of intravenouisly delivering anti-transferrin antibody/oligonucleotide complexes to subjects having muscular dystrophy

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Patent Citations Received

US Patent 12128109 Muscle targeting complexes and formulations for treating dystrophinopathies

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US Patent 11833217 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 11911484 Muscle targeting complexes and uses thereof for treating myotonic dystrophy

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US Patent 11931421 Muscle targeting complexes and formulations for treating myotonic dystrophy

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US Patent 11969475 Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy

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US Patent 11986537 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 12005124 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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US Patent 12012460 Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide

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Patent Primary Examiner

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CPC Code

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Aspects of the disclosure relate to antibodies that bind to transferrin receptor (e.g., transferrin receptor 1) and complexes comprising the antibody covalently linked to a molecular payload. Methods of using the antibodies are also provided.

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