Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jing Deng0
Hongzhi Miao0
Hao Li0
Dong Chen0
EunGi Kim0
Trupta Purohit0
Tomasz Cierpicki0
Szymon Klossowski0
...
Date of Patent
April 25, 2023
0Patent Application Number
174683080
Date Filed
September 7, 2021
0Patent Primary Examiner
Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.
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