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US Patent 11591409 Anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof

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Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
115914090
Date of Patent
February 28, 2023
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Patent Application Number
164982230
Date Filed
March 28, 2018
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Patent Citations
‌
US Patent 10344050 Production of heterodimeric proteins
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Patent Primary Examiner
‌
Brad Duffy
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Provided are an anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and a preparation thereof. In particular, provided are a highly stable heterodimeric anti-PD-L1/anti-PD-1 bispecific antibody with characteristics of a natural IgG and without mismatches heavy chain-light chain, and a preparation thereof. The bispecific antibody can bind to both target molecules and is more effective in treating a complex disease.

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