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US Patent 11572402 Method for promoting diversification of antibody variable region

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Chiome Bioscience
Chiome Bioscience
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Current Assignee
Chiome Bioscience
Chiome Bioscience
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
115724020
Date of Patent
February 7, 2023
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Patent Application Number
164840610
Date Filed
February 9, 2018
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Patent Primary Examiner
‌
Daniel E Kolker
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CPC Code
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C07K 2317/23
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C07K 2317/24
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C12N 5/16
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C12N 15/09
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C07K 2317/14
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C07K 16/00
0

The present invention relates to a method for promoting diversification of variable regions of an antibody. Specifically, the present invention relates to a method for promoting diversification of the amino acid sequences of variable regions of an antibody generated by an avian B cell population, wherein the method comprises suppressing the PI3Kα activity of each avian B cell comprised in the avian B cell population expressing the antibody.

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