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US Patent 11572359 PARP/PI3K double-target inhibit containing pyridopyrimidine structure

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Current Assignee
China Pharmaceutical University
China Pharmaceutical University
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11572359
Date of Patent
February 7, 2023
Patent Application Number
16769893
Date Filed
August 1, 2018
Patent Primary Examiner
‌
John M Mauro
CPC Code
‌
A61P 35/00
‌
B01J 31/28
‌
B01J 31/2404
‌
B01J 2231/4211
‌
B01J 2531/824
‌
A61K 31/5377
‌
C07D 471/04

The present disclosure relates to the field of pharmaceutical chemistry, in particular to a class of PARP/PI3K double-target inhibitors (I) containing structures of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazin-1(2H)-one and a preparation method thereof. As proved by pharmacodynamic tests, the compounds of the present disclosure have PARP/PI3K double-target inhibitory activity and can be used for anti-tumor.

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