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US Patent 11545234 Decoding approaches for protein identification

Patent 11545234 was granted and assigned to Nautilus Biotechnology on January, 2023 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
0

Patent attributes

Patent Applicant
Nautilus Biotechnology
Nautilus Biotechnology
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Current Assignee
Nautilus Biotechnology
Nautilus Biotechnology
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
115452340
Patent Inventor Names
Sujal M. Patel0
Jarrett D. Egertson0
Parag Mallick0
Date of Patent
January 3, 2023
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Patent Application Number
172214310
Date Filed
April 2, 2021
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Patent Citations
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US Patent 10829816 Methods of analyte detection
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US Patent 10175248 Methods of polypeptide identification, and compositions therefor
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US Patent 10571473 Methods of polypeptide identification, and compositions therefor
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US Patent 10921317 Methods of assaying proteins
Patent Primary Examiner
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Robert J Eom
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CPC Code
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G01N 27/60
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G01N 27/72
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G16B 5/20
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G01N 27/26
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Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.

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