Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Diane Tribble0
Susan M. Freier0
Sanjay Bhanot0
Rosanne M. Crooke0
Mark J. Graham0
Kristina M. Lemonidis0
Andrew T. Watt0
Date of Patent
December 20, 2022
0Patent Application Number
170325500
Date Filed
September 25, 2020
0Patent Citations
Patent Primary Examiner
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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