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US Patent 11458167 Bispecific CAR T-cells for solid tumor targeting

Patent 11458167 was granted and assigned to Seattle Children's on October, 2022 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
Seattle Children's
Seattle Children's
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Current Assignee
Seattle Children's
Seattle Children's
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
114581670
Patent Inventor Names
Michael C. Jensen0
Date of Patent
October 4, 2022
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Patent Application Number
157507080
Date Filed
August 3, 2016
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Patent Citations
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US Patent 10266592 Drug regulated transgene expression
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US Patent 10125193 Chimeric antigen receptors and methods of making
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US Patent 10172885 Cell
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US Patent 10221245 Treatment of cancer using humanized anti-CD19 chimeric antigen receptor
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US Patent 10287350 Chimeric antigen receptors targeting CD-19
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US Patent 10358474 Compositions and methods for TCR reprogramming using fusion proteins
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US Patent 10457730 Chimeric antigen receptor (CAR) comprising a CD19-binding domain
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US Patent 10533055 Antibodies and chimeric antigen receptors specific for CD19
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Patent Primary Examiner
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Phuong Huynh
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CPC Code
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A61K 31/713
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A61K 45/06
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A61K 38/00
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A61K 2300/00
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A61P 35/00
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C07K 14/7051
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C07K 14/70578
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C07K 16/28
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Disclosed herein are methods of engineering a bi-specific T-cell expressing chimeric antigen receptors for promoting the in vivo expansion and activation of an effector cell and a second chimeric antigen receptor or TcR specific for a ligand on a tumor. Methods of administering to subjects in need, bi-specific chimeric antigen receptor bearing cells are also provided.

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