An automatic loading and unloading device includes a frame, an unloading unit, a receiving unit and a receiving link unit. The frame defines a processing area, an unloading area and a receiving area. The unloading unit includes an unloading slide rail, and an unloading drive group movably disposed on the unloading slide rail for driving at least one plate to move from the processing area to the unloading area. The receiving unit includes a receiving slide rail, and a receiving lift group movably disposed on the receiving slide rail for driving the at least one plate to move from the unloading area to the receiving area. The receiving link unit interconnects the unloading drive group and the receiving lift group.