Patent 11389439 was granted and assigned to The Jackson Laboratory on July, 2022 by the United States Patent and Trademark Office.
The invention relates to the use of a pharmaceutical composition containing nicotinamide (NAM) and/or pyruvate as a neuroprotective medicament or gene therapy in the treatment of neurodegenerative disorders, in particular axon degeneration of neuronal tissue in ocular-related neurodegeneration diseases including glaucoma.