Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Aaron Martin0
Jon E. Chatterton0
Date of Patent
July 12, 2022
Patent Application Number
17511022
Date Filed
October 26, 2021
Patent Citations
Patent Primary Examiner
CPC Code
The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
