A hybrid cable for use with sensitive detectors may include a central power delivery component, a data delivery component positioned around the power delivery component, and a jacket formed around the power delivery component and the data delivery component. The power delivery component may include a plurality of shielded first individually insulated conductors. The data delivery component may include four twisted pairs of second individually insulated conductors and respective shield layers formed around each of the four pairs. An outer diameter of the cable may be less than 8.5 mm, and the cable may be capable of transmitting data within an operating frequency range of up to 2.5 GHz over a distance of at least 100 m.