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US Patent 11324796 Method for regulating lipolysis and fatty acid oxidative metabolism

Patent 11324796 was granted and assigned to Nanjing University on May, 2022 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Nanjing University
Nanjing University
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Current Assignee
Nanjing University
Nanjing University
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
113247960
Patent Inventor Names
Zhuang Hongqin0
Hua Zichun0
Date of Patent
May 10, 2022
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Patent Application Number
163112210
Date Filed
November 24, 2016
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Patent Primary Examiner
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Marcela M Cordero Garcia
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CPC Code
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A61K 45/00
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A61K 48/00
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A61P 3/00
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A61P 3/04
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A61K 31/715
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G01N 33/68
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A61K 31/7088
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A61K 31/20
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Provided are a method for promoting the lipolysis and fatty acid oxidative metabolism in mammals or cells derived from mammals, a method for downregulating the fat content and the weight of a mammalian body, as well as a method for increasing the intracellular cAMP concentration, increasing the phosphorylation degree and the activity of the hormone-sensitive esterase HSL, enhancing the transcription activity of PPAR alpha and increasing the activities of enzymes involved in a fatty acid beta oxidation process. By simulating the expression of a protein corresponding to a gene responsible for the phosphorylation of the Fas-associated death domain protein, or treating and acting on mammals or cells derived from mammals with a material that can increase the phosphorylation degree of the Fas-associated death domain protein, said methods increases the phosphorylation of the Fas-associated death domain protein.

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