Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Holly Koblish0
Gary Reuther0
Date of Patent
March 22, 2022
0Patent Application Number
167836630
Date Filed
February 6, 2020
0Patent Citations
Patent Primary Examiner
CPC Code
The present application relates to treatment of myeloproliferative neoplasms using the JAK1/JAK2 inhibitor, ruxolitinib, in combination with a low dose of a Pim inhibitor, N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, wherein the combination is unexpectedly synergistic at a very low dose of the Pim inhibitor.
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