Patent 11187697 was granted and assigned to Takeda Pharmaceutical Company on November, 2021 by the United States Patent and Trademark Office.
The present invention provides, among other things, improved substrate clearance assays for lysosomal enzyme that are particularly useful for measuring potency of lysosomal enzymes or other therapeutics for treatment of lysosomal storage diseases. In particular, the present invention combines a physiologically relevant substrate cell assay and an efficient scintillation based detection method.