The present disclosure may provide a method for segmenting an image. The method may include obtaining an image and related information. The image may include a tumor region. The method may also include determining a region of interest in the image. The region of interest may include the tumor region. The method may also include performing a first segmentation of the region of interest to obtain a first segmentation result. The first segmentation may include: determining tumor morphology relating to the tumor region; performing a second segmentation of the region of interest to obtain a second segmentation result; and optimizing, based on the tumor morphology, the second segmentation result to obtain the first segmentation result.